Endocrine Abstracts

Objective: AGEs, compounds formed by the transformation of proteins, are increased in conditions of oxidative stress and promote inflammation by interacting with their receptor (RAGE) on cell membrane. By contrast, the soluble receptor for AGE (sRAGE), that is proteolytically cleaved from cell surface receptor via matrix metalloproteinases, sequester RAGE ligands and act as a cytoprotective and anti-inflammatory agent. AGEs/sRAGE interaction play a role in the pathogenesis of ...

Background: IL-37, member of the IL-1 family, is a natural suppressor of immune and inflammatory responses. Increased serum IL-37 levels were observed in several autoimmune diseases, including Graves’ disease. No data on TH are available from the literature.Materials and methods: We enrolled 45 euthyroid HT patients (5 M e 40 F, mean age 38.5±12.6) and 50 age- and sex-matched healthy controls. None was on LT-4 therapy. Smokers, subjects with ki...

The work-up of Differentiated Thyroid Cancer (DTC) patients includes thyroid surgery, thyroid remnant ablation (TRA) with 131-radioiodine and long life follow-up. 131I-post therapy whole body scan (pT-WBS) and thyroglobulin (Tg) are used in identifying metastatic patients. Some authors suggested to use post-surgical Tg (ps-Tg) values in deciding for or against TRA. The aim of our study was to verify the sensitivity and PPV of 131I-pT-WBS compared to serum Tg levels in detectin...